Twenty-four-hour efficacy of the brinzolamide 1%/brimonidine 0.2% fixed combination: what does the new evidence tell us?

The importance of 24-hour intraocular pressure (IOP) assessment has increasingly being recognized in recent years (1-4). In cardiology, 24-hour blood pressure monitoring is widely employed to accurately characterize a patient’s blood pressure profile and to guide management. Similarly, in glaucoma care 24-hour IOP assessment can delineate a patient’s true pressure characteristics and guide stepwise decision-making (1,5). Nevertheless, the precise predictive value of a short-term 24-hour untreated, or treated curve upon the long-term prognosis of glaucoma remains to be elucidated.